METABOLISM OF VIT-D AND CALCIUM WITH RICKETS AND OSTEOMALACIA
0 10 August 2017

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Dr.M.ARAVINDH., MBBS

INTRODUCTION

1. Vit –D is a fat soluable vitamin that helps in normal bone growth in a child and that gets absorbed in intestine and also produced by skin when exposed to sunlight(UV rays).

2. Plays a major role in calcium ,phosphate regulation in our body.

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VIT – D RICH ITEMS :

  • MILK ,BREAST MILK
  • DAIRY PRODUCTS – BUTTER,CHEESE
  • FORTIFIED CEREALS
  • FISH OIL
  • EGG YOLK
  • GREEN LEAF VEGETABLES

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RICKETS :

  • Inadequate or defective mineralization of growing bone before epiphyseal growth in children.
  • More common in < 4 yrs of age.
  • Incidence 24.1 per 100,000 in 2000 overall.
  • Incidence 38 per 100,000 since yr 2000 in india.

TYPES OF RICKETS :

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CLINICAL FEATURES:

lethargy

  • Joint Pain
  • Muscle Ache and Weakness
  • Decreased Activity of the Child
  • Tiredness
  • Loss of Hair or thin Hair
  • Thickening of wrist
  • Seizures
  • Short Stature

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NUTRITIONAL RICKETS :

  • Lack of dietary intake .
  • Defective production vit –d in skin due to decreased exposure to sun light.
  • Common rickets in India

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SECONDARY RICKETSSECONDARY RICKETS :

  • RENAL TUBULAR ACIDOSIS
  • CHRONIC KIDNEY DISEASE
  • ONCOGENIC RICKETS
  • METAPHYSEAL DYSPLASIA
  • FLUOROSIS

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OSTEOMALACIA :

  • Inadequate or defective mineralization of bone after epiphyseal closure in adults.
  • Leads to fragile or soft bone formation.
  • Due to vit –d deficiency.

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CAUSES:

1.Short bowel syndrome(intestine bypass surgery)

  • Hypophosphatemia,hypoparathyroidism,RF
  • Drugs like barbiturates,phenytoin,rifampicin
  • VITAMIN D deficiency and malabsorption

Impaired mineralization of bone matrix proteins

  • Bowing of weight bearing bones(DEFORMITIES)
  • (KNOCK KNEES)
  • Skeletal fractures

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Prevention :

    • Vitamin d rich diet like

milk , egg , green leaf vegetables

  • Plenty of sleep
  • Regular exercise
  • Sunlight exposure

COMPLICATIONS :

  • SECONDARY HYPERPARATHYROIDISM
  • REPIRATORY DISTRESS
  • Tetany , psuedofractures
  • CARDIOVASCULAR ABNORMALITIES
  • SKELETAL DEFORMITIES
  • SIEZURES
  • Proximal MYOPATHY
  • DEATH

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